Novel Orthobunyavirus Identified in the Cerebrospinal Fluid of a Ugandan Child With Severe Encephalopathy | Zendy

Arthur W. D. Edridge | Zendy; Martin Deijs | Zendy; Ruth Namazzi | Zendy; Cosimo Cristella | Zendy; Maarten F. Jebbink | Zendy; Irma Maurer | Zendy; Neeltje A. Kootstra | Zendy; Linda Rosset Buluma | Zendy; Job B. M. van Woensel | Zendy; M.C.M. de Jong | Zendy; Richard Idro | Zendy; Michaël Boele van Hensbroek | Zendy; Lia van der Hoek | Zendy

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Novel Orthobunyavirus Identified in the Cerebrospinal Fluid of a Ugandan Child With Severe Encephalopathy

Author(s) -

Arthur W. D. Edridge,

Martin Deijs,

Ruth Namazzi,

Cosimo Cristella,

Maarten F. Jebbink,

Irma Maurer,

Neeltje A. Kootstra,

Linda Rosset Buluma,

Job B. M. van Woensel,

M.C.M. de Jong,

Richard Idro,

Michaël Boele van Hensbroek,

Lia van der Hoek

Publication year - 2018

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciy486

Subject(s) - orthobunyavirus , medicine , acute flaccid paralysis , typing , encephalopathy , virology , metagenomics , encephalitis , cerebrospinal fluid , virus , viral encephalitis , microbiology and biotechnology , pathology , biology , genetics , gene , poliovirus

A Ugandan child with an unexplained encephalitis was investigated using viral metagenomics. Several sequences from all segments of a novel orthobunyavirus were found. The S-segment, used for typing, showed 41% amino acid diversity to its closest relative. The virus was named Ntwetwe virus, after the hometown of the patient.

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