Increased Metabolic Activity on 18F-Fluorodeoxyglucose Positron Emission Tomography–Computed Tomography in Human Immunodeficiency Virus–Associated Immune Reconstitution Inflammatory Syndrome | Zendy

Dima A. Hammoud | Zendy; Afroditi Boulougoura | Zendy; Georgios Z. Papadakis | Zendy; Jing Wang | Zendy; Lori E. Dodd | Zendy; Adam Rupert | Zendy; Jeanette Higgins | Zendy; Gregg Roby | Zendy; Dorinda Metzger | Zendy; Elizabeth Laidlaw | Zendy; JoAnn M. Mican | Zendy; Alice K. Pau | Zendy; Silvia Lucena Lage | Zendy; Chun-Shu Wong | Zendy; Andrea Lisco | Zendy; Maura Manion | Zendy; Virginia Sheikh | Zendy; Corina Millo | Zendy; Irini Sereti | Zendy

Open Access

Increased Metabolic Activity on 18F-Fluorodeoxyglucose Positron Emission Tomography–Computed Tomography in Human Immunodeficiency Virus–Associated Immune Reconstitution Inflammatory Syndrome

Author(s) -

Dima A. Hammoud,

Afroditi Boulougoura,

Georgios Z. Papadakis,

Jing Wang,

Lori E. Dodd,

Adam Rupert,

Jeanette Higgins,

Gregg Roby,

Dorinda Metzger,

Elizabeth Laidlaw,

JoAnn M. Mican,

Alice K. Pau,

Silvia Lucena Lage,

Chun-Shu Wong,

Andrea Lisco,

Maura Manion,

Virginia Sheikh,

Corina Millo,

Irini Sereti

Publication year - 2018

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciy454

Subject(s) - immune reconstitution inflammatory syndrome , medicine , positron emission tomography , spleen , pet ct , fluorodeoxyglucose , prospective cohort study , pathology , tuberculosis , immunology , gastroenterology , virus , viral load , nuclear medicine , antiretroviral therapy

Immune reconstitution inflammatory syndrome (IRIS) represents an unexpected inflammatory response shortly after initiation of antiretroviral therapy (ART) in some human immunodeficiency virus (HIV)-infected patients with underlying neoplasia or opportunistic infections, including tuberculosis. We hypothesized that IRIS is associated with increased glycolysis and that 18F-fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET/CT) could help identify high-risk subjects.

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