Difficult-to-Treat Resistance in Gram-negative Bacteremia at 173 US Hospitals: Retrospective Cohort Analysis of Prevalence, Predictors, and Outcome of Resistance to All First-line Agents | Zendy

Sameer S. Kadri | Zendy; Jennifer Adjemian | Zendy; Yi Ling Lai | Zendy; Alicen B. Spaulding | Zendy; Emily Ricotta | Zendy; D. Rebecca Prevots | Zendy; Tara N. Palmore | Zendy; Chanu Rhee | Zendy; Michael Klompas | Zendy; John P. Dekker | Zendy; John H. Powers | Zendy; Anthony F. Suffredini | Zendy; David C. Hooper | Zendy; Scott K. Fridkin | Zendy; Robert L. Danner | Zendy

Open Access

Difficult-to-Treat Resistance in Gram-negative Bacteremia at 173 US Hospitals: Retrospective Cohort Analysis of Prevalence, Predictors, and Outcome of Resistance to All First-line Agents

Author(s) -

Sameer S. Kadri,

Jennifer Adjemian,

Yi Ling Lai,

Alicen B. Spaulding,

Emily Ricotta,

D. Rebecca Prevots,

Tara N. Palmore,

Chanu Rhee,

Michael Klompas,

John P. Dekker,

John H. Powers,

Anthony F. Suffredini,

David C. Hooper,

Scott K. Fridkin,

Robert L. Danner

Publication year - 2018

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciy378

Subject(s) - medicine , bacteremia , cohort , retrospective cohort study , gram , gram negative bacterial infections , intensive care medicine , antibiotics , microbiology and biotechnology , bacteria , genetics , biology

Resistance to all first-line antibiotics necessitates the use of less effective or more toxic "reserve" agents. Gram-negative bloodstream infections (GNBSIs) harboring such difficult-to-treat resistance (DTR) may have higher mortality than phenotypes that allow for ≥1 active first-line antibiotic.

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