Comparison of the Cumulative Efficacy and Safety of Chloroquine, Artesunate, and Chloroquine-Primaquine in Plasmodium vivax Malaria | Zendy

Cindy S. Chu | Zendy; Aung Pyae Phyo | Zendy; Khin Maung Lwin | Zendy; Htun Htun Win | Zendy; Thida San | Zendy; Aye Aye Aung | Zendy; Rattanaporn Raksapraidee | Zendy; Verena I. Carrara | Zendy; Germana Bancone | Zendy; James A Watson | Zendy; Kerryn A. Moore | Zendy; Jacher Wiladphaingern | Zendy; Stéphane Proux | Zendy; Kanlaya Sriprawat | Zendy; Markus Winterberg | Zendy; Phaik Yeong Cheah | Zendy; Amy L Chue | Zendy; Joel Tärning | Zendy; Mallika Imwong | Zendy; François Nosten | Zendy; Nicholas J. White | Zendy

Open Access

Comparison of the Cumulative Efficacy and Safety of Chloroquine, Artesunate, and Chloroquine-Primaquine in Plasmodium vivax Malaria

Author(s) -

Cindy S. Chu,

Aung Pyae Phyo,

Khin Maung Lwin,

Htun Htun Win,

Thida San,

Aye Aye Aung,

Rattanaporn Raksapraidee,

Verena I. Carrara,

Germana Bancone,

James A Watson,

Kerryn A. Moore,

Jacher Wiladphaingern,

Stéphane Proux,

Kanlaya Sriprawat,

Markus Winterberg,

Phaik Yeong Cheah,

Amy L Chue,

Joel Tärning,

Mallika Imwong,

François Nosten,

Nicholas J. White

Publication year - 2018

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciy319

Subject(s) - primaquine , chloroquine , plasmodium vivax , malaria , artesunate , medicine , vivax malaria , hemolysis , piperaquine , hematocrit , pharmacology , virology , plasmodium falciparum , immunology , artemisinin

Chloroquine has been recommended for Plasmodium vivax infections for >60 years, but resistance is increasing. To guide future therapies, the cumulative benefits of using slowly eliminated (chloroquine) vs rapidly eliminated (artesunate) antimalarials, and the risks and benefits of adding radical cure (primaquine) were assessed in a 3-way randomized comparison conducted on the Thailand-Myanmar border.

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