Pneumocystis Cytochrome b Mutants Associated With Atovaquone Prophylaxis Failure as the Cause of Pneumocystis Infection Outbreak Among Heart Transplant Recipients | Zendy

Nicolas Argy | Zendy; Solène Le Gal | Zendy; Romain Coppée | Zendy; Zehua Song | Zendy; William Vindrios | Zendy; Laurent Massias | Zendy; WeiChun Kao | Zendy; Carola Hunte | Zendy; Yazdan Yazdanpanah | Zendy; JeanChristophe Lucet | Zendy; Sandrine Houzé | Zendy; Jérôme Clain | Zendy; Gilles Nevez | Zendy

Open Access

Pneumocystis Cytochrome b Mutants Associated With Atovaquone Prophylaxis Failure as the Cause of Pneumocystis Infection Outbreak Among Heart Transplant Recipients

Author(s) -

Nicolas Argy,

Solène Le Gal,

Romain Coppée,

Zehua Song,

William Vindrios,

Laurent Massias,

WeiChun Kao,

Carola Hunte,

Yazdan Yazdanpanah,

JeanChristophe Lucet,

Sandrine Houzé,

Jérôme Clain,

Gilles Nevez

Publication year - 2018

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciy154

Subject(s) - medicine , atovaquone , outbreak , opportunistic infection , virology , immunology , microbiology and biotechnology , human immunodeficiency virus (hiv) , viral disease , biology , plasmodium falciparum , malaria

Although trimethoprim-sulfamethoxazole is the more efficient drug for prophylactic and curative treatment of pneumocystosis, atovaquone is considered a second-line prophylactic treatment in immunocompromised patients. Variations in atovaquone absorption and mutant fungi selection after atovaquone exposure have been associated with atovaquone prophylactic failure. We report here a Pneumocystis jirovecii cytochrome b (cyt b) mutation (A144V) associated with such prophylactic failure during a pneumocystosis outbreak among heart transplant recipients.

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