First-in-human, Randomized, Double-blind Clinical Trial of Differentially Adjuvanted PAMVAC, A Vaccine Candidate to Prevent Pregnancy-associated Malaria | Zendy

Benjamin Mordmüller | Zendy; Mihály Sulyok | Zendy; Diane EggerAdam | Zendy; Mafalda Resende | Zendy; Willem A. de Jongh | Zendy; M. Jensen | Zendy; Helle Holm Smedegaard | Zendy; Sisse B. Ditlev | Zendy; Max Soegaard | Zendy; Lars Poulsen | Zendy; Charlotte Dyring | Zendy; Carlos Lamsfus Calle | Zendy; Annette Knoblich | Zendy; Javier Ibáñez | Zendy; Meral Esen | Zendy; Philippe Deloron | Zendy; Nicaise Tuikue Ndam | Zendy; Saadou Issifou | Zendy; Sophie Houard | Zendy; Randall F. Howard | Zendy; Steven G. Reed | Zendy; Odile Leroy | Zendy; Adrian J. F. Luty | Zendy; Thor G. Theander | Zendy; Peter G. Kremsner | Zendy; Ali Salanti | Zendy; Morten A. Nielsen | Zendy

Open Access

First-in-human, Randomized, Double-blind Clinical Trial of Differentially Adjuvanted PAMVAC, A Vaccine Candidate to Prevent Pregnancy-associated Malaria

Author(s) -

Benjamin Mordmüller,

Mihály Sulyok,

Diane EggerAdam,

Mafalda Resende,

Willem A. de Jongh,

M. Jensen,

Helle Holm Smedegaard,

Sisse B. Ditlev,

Max Soegaard,

Lars Poulsen,

Charlotte Dyring,

Carlos Lamsfus Calle,

Annette Knoblich,

Javier Ibáñez,

Meral Esen,

Philippe Deloron,

Nicaise Tuikue Ndam,

Saadou Issifou,

Sophie Houard,

Randall F. Howard,

Steven G. Reed,

Odile Leroy,

Adrian J. F. Luty,

Thor G. Theander,

Peter G. Kremsner,

Ali Salanti,

Morten A. Nielsen

Publication year - 2019

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciy1140

Subject(s) - medicine , double blind , malaria , malaria vaccine , randomized controlled trial , pregnancy , clinical trial , virology , immunology , plasmodium falciparum , alternative medicine , placebo , pathology , biology , genetics

Malaria in pregnancy has major impacts on mother and child health. To complement existing interventions, such as intermittent preventive treatment and use of impregnated bed nets, we developed a malaria vaccine candidate with the aim of reducing sequestration of asexual "blood-stage" parasites in the placenta, the major virulence mechanism.

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