The Design and Analysis of Seroefficacy Studies for Typhoid Conjugate Vaccines | Zendy

Xinxue Liu | Zendy; Virginia E. Pitzer | Zendy; Andrew J. Pollard | Zendy; Merryn Voysey | Zendy

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The Design and Analysis of Seroefficacy Studies for Typhoid Conjugate Vaccines

Author(s) -

Xinxue Liu,

Virginia E. Pitzer,

Andrew J. Pollard,

Merryn Voysey

Publication year - 2019

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciy1119

Subject(s) - medicine , typhoid fever , clinical trial , vaccine trial , typhoid vaccine , relative risk , sample size determination , immunology , virology , statistics , confidence interval , mathematics

Demonstrating the efficacy of new Vi-conjugate typhoid vaccines is challenging, due to the cost of field trials requiring tens of thousands of participants. New trial designs that use serologically defined typhoid infections (seroefficacy trials) rather than blood culture positivity as a study endpoint may be useful to assess efficacy using small trials.

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