Assessing the Impact of a Vi-polysaccharide Conjugate Vaccine in Preventing Typhoid Infections Among Nepalese Children: A Protocol for a Phase III, Randomized Control Trial | Zendy

Katherine Theiss-Nyland | Zendy; Mila Shakya | Zendy; Rachel Colin-Jones | Zendy; Merryn Voysey | Zendy; Nicola Smith | Zendy; Abhilasha Karkey | Zendy; Sabina Dongol | Zendy; Dikshya Pant | Zendy; Yama F Mujadidi | Zendy; Kathleen M. Neuzil | Zendy; Shrijana Shrestha | Zendy; Buddha Basnyat | Zendy; Andrew J. Pollard | Zendy

Open Access

Assessing the Impact of a Vi-polysaccharide Conjugate Vaccine in Preventing Typhoid Infections Among Nepalese Children: A Protocol for a Phase III, Randomized Control Trial

Author(s) -

Katherine Theiss-Nyland,

Mila Shakya,

Rachel Colin-Jones,

Merryn Voysey,

Nicola Smith,

Abhilasha Karkey,

Sabina Dongol,

Dikshya Pant,

Yama F Mujadidi,

Kathleen M. Neuzil,

Shrijana Shrestha,

Buddha Basnyat,

Andrew J. Pollard

Publication year - 2019

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciy1106

Subject(s) - medicine , typhoid fever , randomized controlled trial , environmental health , sanitation , conjugate vaccine , population , public health , vaccination , pediatrics , immunization , immunology , virology , nursing , antigen , pathology

Enteric fever is estimated to affect 11-20 million people worldwide each year. Morbidity and mortality from enteric fever primarily occur in lower-income countries, with children under 5 years of age experiencing a significant portion of the burden. Over the last few decades, the control of enteric fever has focused primarily on improved water and sanitation, with the available vaccines unsuitable for children and primarily used by travelers. A new typhoid conjugate vaccine (Vi-TCV), prequalified by the World Health Organization (WHO) and highly immunogenic in children under 5, has the potential to reduce the typhoid burden in endemic countries.

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