Passage Adaptation Correlates With the Reduced Efficacy of the Influenza Vaccine | Zendy

Hui Chen | Zendy; Jacob J.S. Alvarez | Zendy; Sock Hoon Ng | Zendy; Rasmus Nielsen | Zendy; Weiwei Zhai | Zendy

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Passage Adaptation Correlates With the Reduced Efficacy of the Influenza Vaccine

Author(s) -

Hui Chen,

Jacob J.S. Alvarez,

Sock Hoon Ng,

Rasmus Nielsen,

Weiwei Zhai

Publication year - 2018

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciy1065

Subject(s) - embryonated , vaccine efficacy , adaptation (eye) , hemagglutinin (influenza) , biology , virus , virology , influenza vaccine , evolutionary biology , antigenic drift , genetics , computational biology , vaccination , neuroscience

As a dominant seasonal influenza virus, H3N2 virus rapidly evolves in humans and is a constant threat to public health. Despite sustained research efforts, the efficacy of H3N2 vaccine has decreased rapidly. Even though antigenic drift and passage adaptation (substitutions accumulated during vaccine production in embryonated eggs) have been implicated in reduced vaccine efficacy (VE), their respective contributions to the phenomenon remain controversial.

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