Human Direct Skin Feeding Versus Membrane Feeding to Assess the Mosquitocidal Efficacy of High-Dose Ivermectin (IVERMAL Trial) | Zendy

Menno R. Smit | Zendy; Eric Ochomo | Zendy; Ghaith Aljayyoussi | Zendy; Titus K. Kwambai | Zendy; Bernard Abong’o | Zendy; Teun Bousema | Zendy; David Waterhouse | Zendy; Nabie Bayoh | Zendy; John E. Gimnig | Zendy; Aaron M. Samuels | Zendy; Meghna Desai | Zendy; Penelope A. Phillips–Howard | Zendy; Simon Kariuki | Zendy; Duolao Wang | Zendy; Stephen A. Ward | Zendy; Feiko O. ter Kuile | Zendy

Open Access

Human Direct Skin Feeding Versus Membrane Feeding to Assess the Mosquitocidal Efficacy of High-Dose Ivermectin (IVERMAL Trial)

Author(s) -

Menno R. Smit,

Eric Ochomo,

Ghaith Aljayyoussi,

Titus K. Kwambai,

Bernard Abong’o,

Teun Bousema,

David Waterhouse,

Nabie Bayoh,

John E. Gimnig,

Aaron M. Samuels,

Meghna Desai,

Penelope A. Phillips–Howard,

Simon Kariuki,

Duolao Wang,

Stephen A. Ward,

Feiko O. ter Kuile

Publication year - 2018

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciy1063

Subject(s) - ivermectin , medicine , anopheles gambiae , malaria , placebo , confidence interval , veterinary medicine , immunology , pathology , alternative medicine

Ivermectin is being considered for mass drug administration for malaria, due to its ability to kill mosquitoes feeding on recently treated individuals. In a recent trial, 3-day courses of 300 and 600 mcg/kg/day were shown to kill Anopheles mosquitoes for at least 28 days post-treatment when fed patients' venous blood using membrane feeding assays. Direct skin feeding on humans may lead to higher mosquito mortality, as ivermectin capillary concentrations are higher. We compared mosquito mortality following direct skin and membrane feeding.

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