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Impact of De-escalation on Prognosis of Patients With Bacteremia due to Enterobacteriaceae: A Post Hoc Analysis From a Multicenter Prospective Cohort
Author(s) -
Zaira R. PalaciosBaena,
Mercedes Delgado-Valverde,
Adoración Valiente Méndez,
Benito Almirante,
Sílvia Gómez-Zorrilla,
Núria Borrell,
Juan E. Corzo,
M. Gurguí,
Cristina de la Calle,
Lara García-Álvarez,
Lucía Ramos,
Mónica Gozalo,
María Isabel Morosini,
José Molina,
Manuel Causse,
Álvaro Pascual,
Jesús RodríguezBaño,
Marina de Cueto,
A. Moreno Reig,
F Tubau Quintano,
Carmen Peña,
M E Galán Otalora,
C. Ruiz de Alegría,
Rafael Cantón,
José Antonio Lepe,
José Miguel Cisneros,
Julián Torre-Cisneros,
Raúl Lara
Publication year - 2018
Publication title -
clinical infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/cid/ciy1032
Subject(s) - medicine , ertapenem , confidence interval , bacteremia , hazard ratio , odds ratio , meropenem , imipenem , de escalation , prospective cohort study , proportional hazards model , logistic regression , antibiotics , antibiotic resistance , microbiology and biotechnology , biology
More data are needed about the safety of antibiotic de-escalation in specific clinical situations as a strategy to reduce exposure to broad-spectrum antibiotics. The aims of this study were to investigate predictors of de-escalation and its impact on the outcome of patients with bloodstream infection due to Enterobacteriaceae (BSI-E).

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