Clonal Emergence of Invasive Multidrug-Resistant Staphylococcus epidermidis Deconvoluted via a Combination of Whole-Genome Sequencing and Microbiome Analyses | Zendy

Xiqi Li | Zendy; César A. Arias | Zendy; Samuel L Aitken | Zendy; Jessica Galloway-Peña | Zendy; Diana Panesso | Zendy; Michael Chang | Zendy; Lorena Díaz | Zendy; Rafael Ríos | Zendy; Yazan Numan | Zendy; Sammi Ghaoui | Zendy; Sruti DebRoy | Zendy; Micah M. Bhatti | Zendy; Dawn E. Simmons | Zendy; I. Raad | Zendy; Ray Hachem | Zendy; Stephanie A. Folan | Zendy; Pranoti Sahasarabhojane | Zendy; Awdhesh Kalia | Zendy; Samuel A. Shelburne | Zendy

Open Access

Clonal Emergence of Invasive Multidrug-Resistant Staphylococcus epidermidis Deconvoluted via a Combination of Whole-Genome Sequencing and Microbiome Analyses

Author(s) -

Xiqi Li,

César A. Arias,

Samuel L Aitken,

Jessica Galloway-Peña,

Diana Panesso,

Michael Chang,

Lorena Díaz,

Rafael Ríos,

Yazan Numan,

Sammi Ghaoui,

Sruti DebRoy,

Micah M. Bhatti,

Dawn E. Simmons,

I. Raad,

Ray Hachem,

Stephanie A. Folan,

Pranoti Sahasarabhojane,

Awdhesh Kalia,

Samuel A. Shelburne

Publication year - 2018

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciy089

Subject(s) - microbiome , staphylococcus epidermidis , dna sequencing , whole genome sequencing , medicine , computational biology , microbiology and biotechnology , multiple drug resistance , genome , biology , drug resistance , genetics , staphylococcus aureus , bacteria , dna , gene

Pathobionts, bacteria that are typically human commensals but can cause disease, contribute significantly to antimicrobial resistance. Staphylococcus epidermidis is a prototypical pathobiont as it is a ubiquitous human commensal but also a leading cause of healthcare-associated bacteremia. We sought to determine the etiology of a recent increase in invasive S. epidermidis isolates resistant to linezolid.

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