Rotavirus-Specific Immunoglobulin A Responses Are Impaired and Serve as a Suboptimal Correlate of Protection Among Infants in Bangladesh | Zendy

Benjamin Lee | Zendy; Marya P. Carmolli | Zendy; Dorothy M. Dickson | Zendy; E. Ross Colgate | Zendy; Sean A. Diehl | Zendy; Muhammad Ikhtear Uddin | Zendy; Shahidul Islam | Zendy; M. Anowar Hossain | Zendy; Tanzeem Ahmed Rafique | Zendy; Taufiqur Rahman Bhuiyan | Zendy; Masud Alam | Zendy; Uma Nayak | Zendy; Josyf C. Mychaleckyj | Zendy; Monica McNeal | Zendy; William A. Petri | Zendy; Firdausi Qadri | Zendy; Rashidul Haque | Zendy; Beth D. Kirkpatrick | Zendy

Open Access

Rotavirus-Specific Immunoglobulin A Responses Are Impaired and Serve as a Suboptimal Correlate of Protection Among Infants in Bangladesh

Author(s) -

Benjamin Lee,

Marya P. Carmolli,

Dorothy M. Dickson,

E. Ross Colgate,

Sean A. Diehl,

Muhammad Ikhtear Uddin,

Shahidul Islam,

M. Anowar Hossain,

Tanzeem Ahmed Rafique,

Taufiqur Rahman Bhuiyan,

Masud Alam,

Uma Nayak,

Josyf C. Mychaleckyj,

Monica McNeal,

William A. Petri,

Firdausi Qadri,

Rashidul Haque,

Beth D. Kirkpatrick

Publication year - 2018

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciy076

Subject(s) - seroconversion , medicine , rotavirus , immunoglobulin a , immunology , vaccination , antibody , immunogenicity , diarrhea , rotavirus vaccine , immunoglobulin g

Rotavirus (RV)-specific immunoglobulin A (IgA) responses following oral RV vaccination are impaired in low-income countries, where the utility of RV-IgA as a correlate of protection (CoP) remains unclear. In a monovalent oral RV vaccine (Rotarix) efficacy trial among infants in Dhaka, Bangladesh, we identified factors associated with poor RV-IgA responses and explored the utility of RV-IgA as a CoP.

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