Measurement of Human Immunodeficiency Virus p24 Antigen in Human Cerebrospinal Fluid With Digital Enzyme-Linked Immunosorbent Assay and Association With Decreased Neuropsychological Performance | Zendy

Albert M. Anderson | Zendy; William R. Tyor | Zendy; Mark J. Mulligan | Zendy; Drenna WaldropValverde | Zendy; Jeffrey L. Lennox | Zendy; Scott Letendre | Zendy

Open Access

Measurement of Human Immunodeficiency Virus p24 Antigen in Human Cerebrospinal Fluid With Digital Enzyme-Linked Immunosorbent Assay and Association With Decreased Neuropsychological Performance

Author(s) -

Albert M. Anderson,

William R. Tyor,

Mark J. Mulligan,

Drenna WaldropValverde,

Jeffrey L. Lennox,

Scott Letendre

Publication year - 2018

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciy056

Subject(s) - cerebrospinal fluid , medicine , neuropsychology , human immunodeficiency virus (hiv) , antigen , immunology , central nervous system , virology , pathology , psychiatry , cognition

New tools are needed to understand human immunodeficiency virus central nervous system involvement. Testing 15 cerebrospinal fluid (CSF) samples for p24 antigen, using a high-sensitivity assay, we found a strong correlation trend between CSF p24 concentration and worse neuropsychological performance.

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