The Potential for Treatment Shortening With Higher Rifampicin Doses: Relating Drug Exposure to Treatment Response in Patients With Pulmonary Tuberculosis | Zendy

Elin M. Svensson | Zendy; Robin J. Svensson | Zendy; Lindsey H. M. te Brake | Zendy; Martin J. Boeree | Zendy; Norbert Heinrich | Zendy; Sarah Konsten | Zendy; Gavin Churchyard | Zendy; Rodney Dawson | Zendy; Andreas H. Diacon | Zendy; Gibson Kibiki | Zendy; Lilian Tina Minja | Zendy; N. E. Ntingiya | Zendy; Ian Sanne | Zendy; Stephen H. Gillespie | Zendy; Michael Höelscher | Zendy; Patrick Phillips | Zendy; Ulrika S. H. Simonsson | Zendy; Rob E. Aarnoutse | Zendy

Open Access

The Potential for Treatment Shortening With Higher Rifampicin Doses: Relating Drug Exposure to Treatment Response in Patients With Pulmonary Tuberculosis

Author(s) -

Elin M. Svensson,

Robin J. Svensson,

Lindsey H. M. te Brake,

Martin J. Boeree,

Norbert Heinrich,

Sarah Konsten,

Gavin Churchyard,

Rodney Dawson,

Andreas H. Diacon,

Gibson Kibiki,

Lilian Tina Minja,

N. E. Ntingiya,

Ian Sanne,

Stephen H. Gillespie,

Michael Höelscher,

Patrick Phillips,

Ulrika S. H. Simonsson,

Rob E. Aarnoutse

Publication year - 2018

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciy026

Subject(s) - rifampicin , medicine , ethambutol , tuberculosis , culture conversion , pharmacokinetics , moxifloxacin , pharmacology , adverse effect , confidence interval , population , dosing , sputum , antibiotics , microbiology and biotechnology , environmental health , pathology , biology

Tuberculosis remains a huge public health problem and the prolonged treatment duration obstructs effective tuberculosis control. Higher rifampicin doses have been associated with better bactericidal activity, but optimal dosing is uncertain. This analysis aimed to characterize the relationship between rifampicin plasma exposure and treatment response over 6 months in a recent study investigating the potential for treatment shortening with high-dose rifampicin.

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