Genomic Investigation of a Putative Endoscope-Associated Carbapenem-Resistant Enterobacter cloacae Outbreak Reveals a Wide Diversity of Circulating Strains and Resistance Mutations | Zendy

Shawn E. Hawken | Zendy; Laraine Washer | Zendy; Christopher L. Williams | Zendy; Duane W. Newton | Zendy; Evan S. Snitkin | Zendy

Open Access

Genomic Investigation of a Putative Endoscope-Associated Carbapenem-Resistant Enterobacter cloacae Outbreak Reveals a Wide Diversity of Circulating Strains and Resistance Mutations

Author(s) -

Shawn E. Hawken,

Laraine Washer,

Christopher L. Williams,

Duane W. Newton,

Evan S. Snitkin

Publication year - 2017

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cix934

Subject(s) - enterobacter cloacae , outbreak , biology , enterobacter , carbapenem , enterobacteriaceae infections , genetic diversity , microbiology and biotechnology , genetics , virology , gene , enterobacteriaceae , medicine , antibiotics , environmental health , escherichia coli , population

A genomic epidemiologic investigation of a putative carbapenem-resistant Enterobacter cloacae outbreak revealed few plausible instances of nosocomial transmission, highlighting instead the frequent importation of E. cloacae into our hospital. Searching for genetic determinants of carbapenem resistance demonstrated that most resistance is due to convergent mutations in phylogenetically diverse E. cloacae.

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