High Rates of Human Fecal Carriage of mcr-1–Positive Multidrug-Resistant Enterobacteriaceae Emerge in China in Association With Successful Plasmid Families | Zendy

Lan-Lan Zhong | Zendy; Hang Phan | Zendy; Cong Shen | Zendy; Karina-Doris Vihta | Zendy; Anna E. Sheppard | Zendy; Xi Huang | Zendy; Kun-Jiao Zeng | Zendy; Hongyu Li | Zendy; Xue-Fei Zhang | Zendy; Sandip Patil | Zendy; Derrick W. Crook | Zendy; Timothy M. Walker | Zendy; Yongzhong Xing | Zendy; Jia-lin Lin | Zendy; Lian-Qiang Feng | Zendy; Yohei Doi | Zendy; Yong Xia | Zendy; Nicole Stoesser | Zendy; GuoBao Tian | Zendy

Open Access

High Rates of Human Fecal Carriage of mcr-1–Positive Multidrug-Resistant Enterobacteriaceae Emerge in China in Association With Successful Plasmid Families

Author(s) -

Lan-Lan Zhong,

Hang Phan,

Cong Shen,

Karina-Doris Vihta,

Anna E. Sheppard,

Xi Huang,

Kun-Jiao Zeng,

Hongyu Li,

Xue-Fei Zhang,

Sandip Patil,

Derrick W. Crook,

Timothy M. Walker,

Yongzhong Xing,

Jia-lin Lin,

Lian-Qiang Feng,

Yohei Doi,

Yong Xia,

Nicole Stoesser,

GuoBao Tian

Publication year - 2017

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cix885

Subject(s) - enterobacteriaceae , carriage , feces , plasmid , medicine , china , microbiology and biotechnology , multiple drug resistance , mcr 1 , escherichia coli , biology , antibiotics , genetics , gene , geography , pathology , archaeology

mcr-1-mediated colistin resistance in Enterobacteriaceae is concerning, as colistin is used in treating multidrug-resistant Enterobacteriaceae infections. We identified trends in human fecal mcr-1-positivity rates and colonization with mcr-1-positive, third-generation cephalosporin-resistant (3GC-R) Enterobacteriaceae in Guangzhou, China, and investigated the genetic contexts of mcr-1 in mcr-1-positive 3GC-R strains.

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