Metformin Use Reverses the Increased Mortality Associated With Diabetes Mellitus During Tuberculosis Treatment | Zendy

Nicholas Degner | Zendy; JannYuan Wang | Zendy; Jonathan E. Golub | Zendy; Petros C. Karakousis | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Metformin Use Reverses the Increased Mortality Associated With Diabetes Mellitus During Tuberculosis Treatment

Author(s) -

Nicholas Degner,

JannYuan Wang,

Jonathan E. Golub,

Petros C. Karakousis

Publication year - 2017

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cix819

Subject(s) - medicine , metformin , hazard ratio , odds ratio , tuberculosis , retrospective cohort study , diabetes mellitus , sputum culture , confounding , confidence interval , sputum , insulin , endocrinology , pathology

The global type 2 diabetes mellitus (DM) epidemic threatens progress made in reducing tuberculosis (TB)-related mortality worldwide. Previous clinical studies have not fully evaluated potential confounding variables in addressing the impact of DM on TB treatment outcomes. The antidiabetic agent metformin regulates autophagy and may play a role as a host-directed therapeutic adjuvant to antitubercular treatment.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research