DPP4, the Middle East Respiratory Syndrome Coronavirus Receptor, is Upregulated in Lungs of Smokers and Chronic Obstructive Pulmonary Disease Patients | Zendy

Leen Seys | Zendy; W. Widagdo | Zendy; Anne Verhamme | Zendy; Alex KleinJan | Zendy; Wim Janssens | Zendy; Guy Joos | Zendy; Ken R. Bracke | Zendy; Bart L. Haagmans | Zendy; Guy Brusselle | Zendy

Open Access

DPP4, the Middle East Respiratory Syndrome Coronavirus Receptor, is Upregulated in Lungs of Smokers and Chronic Obstructive Pulmonary Disease Patients

Author(s) -

Leen Seys,

W. Widagdo,

Anne Verhamme,

Alex KleinJan,

Wim Janssens,

Guy Joos,

Ken R. Bracke,

Bart L. Haagmans,

Guy Brusselle

Publication year - 2017

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cix741

Subject(s) - medicine , pulmonary disease , downregulation and upregulation , respiratory system , covid-19 , disease , coronavirus , middle east respiratory syndrome coronavirus , immunology , infectious disease (medical specialty) , biology , gene , biochemistry

Middle East respiratory syndrome coronavirus (MERS-CoV) causes pneumonia with a relatively high case fatality rate in humans. Smokers and chronic obstructive pulmonary disease (COPD) patients have been reported to be more susceptible to MERS-CoV infection. Here, we determined the expression of MERS-CoV receptor, dipeptidyl peptidase IV (DPP4), in lung tissues of smokers without airflow limitation and COPD patients in comparison to nonsmoking individuals (never-smokers).

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research