Pan-serotype Reduction in Progression of Streptococcus pneumoniae to Otitis Media After Rollout of Pneumococcal Conjugate Vaccines | Zendy

Joseph A. Lewnard | Zendy; Noga GivonLavi | Zendy; Daniel M. Weinberger | Zendy; Marc Lipsitch | Zendy; Ron Dagan | Zendy

Open Access

Pan-serotype Reduction in Progression of Streptococcus pneumoniae to Otitis Media After Rollout of Pneumococcal Conjugate Vaccines

Author(s) -

Joseph A. Lewnard,

Noga GivonLavi,

Daniel M. Weinberger,

Marc Lipsitch,

Ron Dagan

Publication year - 2017

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cix673

Subject(s) - medicine , streptococcus pneumoniae , serotype , carriage , pneumococcal conjugate vaccine , otitis , pneumococcal infections , population , conjugate vaccine , incidence (geometry) , acute otitis media , immunology , microbiology and biotechnology , immunization , surgery , antigen , biology , antibiotics , environmental health , physics , optics , pathology

Reductions in otitis media (OM) burden following rollout of pneumococcal conjugate vaccines (PCVs) have exceeded predictions of vaccine impact. In settings with active surveillance, reductions in OM caused by vaccine-targeted pneumococcal serotypes have co-occurred with reductions in OM caused by other pathogens carried in the upper-respiratory tract of children. To understand these changes, we investigated the progression of vaccine-targeted and non-vaccine pneumococcal serotypes from carriage to OM before and after vaccine rollout.

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