Successful Therapy of a Multidrug-Resistant Extended-Spectrum β-Lactamase–Producing and Fluoroquinolone-Resistant Salmonella enterica Subspecies enterica Serovar Typhi Infection Using Combination Therapy of Meropenem and Fosfomycin | Zendy

Carola-Ellen Kleine | Zendy; Stefan Schlabe | Zendy; Gunnar Hischebeth | Zendy; Ernst Molitor | Zendy; Yvonne Pfeifer | Zendy; JanChristian Wasmuth | Zendy; Ulrich Spengler | Zendy

Open Access

Successful Therapy of a Multidrug-Resistant Extended-Spectrum β-Lactamase–Producing and Fluoroquinolone-Resistant Salmonella enterica Subspecies enterica Serovar Typhi Infection Using Combination Therapy of Meropenem and Fosfomycin

Author(s) -

Carola-Ellen Kleine,

Stefan Schlabe,

Gunnar Hischebeth,

Ernst Molitor,

Yvonne Pfeifer,

JanChristian Wasmuth,

Ulrich Spengler

Publication year - 2017

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cix652

Subject(s) - fosfomycin , salmonella enterica , meropenem , medicine , microbiology and biotechnology , multiple drug resistance , serotype , quinolone , virology , salmonella , antibiotic resistance , antibiotics , biology , bacteria , genetics

We report a traveler who acquired a Salmonella enterica subspecies enterica serovar Typhi strain with resistance against β-lactams, cephalosporins (extended-spectrum β-lactamase-producing type SHV-12), and quinolones (plasmid-mediated quinolone resistance gene qnrB7). After clinical deterioration using meropenem monotherapy, treatment success was achieved after commencement of fosfomycin in conjunction with high-dose meropenem. The case illustrates clinical challenges of multidrug-resistant S. Typhi.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research