Long-term Use of Proton Pump Inhibitors Is Associated With Increased Microbial Product Translocation, Innate Immune Activation, and Reduced Immunologic Recovery in Patients With Chronic Human Immunodeficiency Virus-1 Infection | Zendy

José A. Serpa | Zendy; Adriana M. Rueda | Zendy; Anoma Somasunderam | Zendy; Netanya S. Utay | Zendy; Daniel J. Lewis | Zendy; Jacob Couturier | Zendy; K. Breaux | Zendy; Maria C. RodriguezBarradas | Zendy

Open Access

Long-term Use of Proton Pump Inhibitors Is Associated With Increased Microbial Product Translocation, Innate Immune Activation, and Reduced Immunologic Recovery in Patients With Chronic Human Immunodeficiency Virus-1 Infection

Author(s) -

José A. Serpa,

Adriana M. Rueda,

Anoma Somasunderam,

Netanya S. Utay,

Daniel J. Lewis,

Jacob Couturier,

K. Breaux,

Maria C. RodriguezBarradas

Publication year - 2017

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cix609

Subject(s) - medicine , immunology , immune system , innate immune system , human immunodeficiency virus (hiv) , immunodeficiency , immunity , virus , chromosomal translocation , virology , biology , biochemistry , gene

Translocation of microbial products from the damaged gut causes increased immune activation in human immunodeficiency virus (HIV). Proton pump inhibitors (PPIs) predispose to bacterial overgrowth in the gut. We hypothesized that long-term use of PPIs is associated with greater microbial translocation and immune activation in HIV.

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