Plasma But Not Cerebrospinal Fluid Interleukin 7 and Interleukin 5 Levels Pre–Antiretroviral Therapy Commencement Predict Cryptococcosis-Associated Immune Reconstitution Inflammatory Syndrome | Zendy

Ngomu Akeem Akilimali | Zendy; Christina C. Chang | Zendy; Daniel M. Muema | Zendy; Tarylee Reddy | Zendy; Mahomed-Yunus S. Moosa | Zendy; Sharon R. Lewin | Zendy; Martyn A. French | Zendy; Thumbi Ndung’u | Zendy

Open Access

Plasma But Not Cerebrospinal Fluid Interleukin 7 and Interleukin 5 Levels Pre–Antiretroviral Therapy Commencement Predict Cryptococcosis-Associated Immune Reconstitution Inflammatory Syndrome

Author(s) -

Ngomu Akeem Akilimali,

Christina C. Chang,

Daniel M. Muema,

Tarylee Reddy,

Mahomed-Yunus S. Moosa,

Sharon R. Lewin,

Martyn A. French,

Thumbi Ndung’u

Publication year - 2017

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cix598

Subject(s) - immune reconstitution inflammatory syndrome , medicine , cerebrospinal fluid , immunology , cytokine , hazard ratio , interleukin , chemokine , immune system , gastroenterology , confidence interval , viral load , antiretroviral therapy , virus

Patients with human immunodeficiency virus/AIDS-associated cryptococcal meningitis (CM) frequently experience clinical deterioration, known as cryptococcosis-associated immune reconstitution inflammatory syndrome (C-IRIS), upon initiation of antiretroviral therapy (ART). The immunological mechanisms underlying C-IRIS are incompletely defined and no reliable predictive biomarkers exist. We investigated whether plasma or cerebrospinal fluid (CSF) levels of cytokines and chemokines predicted C-IRIS and are potential predictive biomarkers.

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