Novel Method Suggests Global Superiority of Short-Duration Antibiotics for Intra-abdominal Infections
Author(s) -
Arthur R Celestin,
Stephen R. Odom,
Konstantia Angelidou,
Scott Evans,
Raúl Coimbra,
Christopher A. Guidry,
Joseph Cuschieri,
Kaysie L. Banton,
Patrick J. O’Neill,
Reza Askari,
Nicholas Namias,
Therèse M. Duane,
Jeffrey A. Claridge,
E. Patchen Dellinger,
Robert G. Sawyer,
Charles H. Cook
Publication year - 2017
Publication title -
clinical infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/cid/cix569
Subject(s) - medicine , antibiotics , duration (music) , antimicrobial , ranking (information retrieval) , intensive care medicine , outcome (game theory) , machine learning , microbiology and biotechnology , art , literature , mathematics , mathematical economics , computer science , biology
Desirability of outcome ranking and response adjusted for duration of antibiotic risk (DOOR/RADAR) are novel and innovative methods of evaluating data in antibiotic trials. We analyzed data from a noninferiority trial of short-course antimicrobial therapy for intra-abdominal infection (STOP-IT), and results suggest global superiority of short-duration therapy for intra-abdominal infections.
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