Viral Load and Cytokine Response Profile Does Not Support Antibody-Dependent Enhancement in Dengue-Primed Zika Virus–Infected Patients | Zendy

Ana Carolina Bernardes Terzian | Zendy; Alessandra SoaresSchanoski | Zendy; Mânlio Tasso de Oliveira Mota | Zendy; Rafael Alves da Silva | Zendy; Cássia Fernanda Estofolete | Zendy; Tatiana Elias Colombo | Zendy; Paula Rahal | Zendy; Kathryn A. Hanley | Zendy; Nikos Vasilakis | Zendy; Jorge Kalil | Zendy; Maurício Lacerda Nogueira | Zendy

Open Access

Viral Load and Cytokine Response Profile Does Not Support Antibody-Dependent Enhancement in Dengue-Primed Zika Virus–Infected Patients

Author(s) -

Ana Carolina Bernardes Terzian,

Alessandra SoaresSchanoski,

Mânlio Tasso de Oliveira Mota,

Rafael Alves da Silva,

Cássia Fernanda Estofolete,

Tatiana Elias Colombo,

Paula Rahal,

Kathryn A. Hanley,

Nikos Vasilakis,

Jorge Kalil,

Maurício Lacerda Nogueira

Publication year - 2017

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cix558

Subject(s) - dengue fever , viremia , dengue virus , zika virus , medicine , immunology , virology , antibody dependent enhancement , viral load , pathogenesis , flavivirus , antibody , virus

The pathogenesis of severe dengue disease involves immune components as biomarkers. The mechanism by which some dengue virus (DENV)-infected individuals progress to severe disease is poorly understood. Most studies on the pathogenesis of severe dengue disease focus on the process of antibody-dependent enhancement (ADE) as a primary risk factor. With the circulation of Zika virus (ZIKV) in DENV-endemic areas, many people infected by ZIKV were likely exposed to DENV. The influence of such exposure on Zika disease outcomes remains unknown.

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