Whole-Genome Cardiac DNA Methylation Fingerprint and Gene Expression Analysis Provide New Insights in the Pathogenesis of Chronic Chagas Disease Cardiomyopathy | Zendy

Laurie Laugier | Zendy; Amanda Farage Frade | Zendy; Frederico Moraes Ferreira | Zendy; Monique Baron | Zendy; Priscila Camillo Teixeira | Zendy; Sandrine Cabantous | Zendy; Ludmila Rodrigues Pinto Ferreira | Zendy; Louis Laurence | Zendy; Vagner Oliveira Carvalho Rigaud | Zendy; Fábio Antônio Gaiotto | Zendy; Fernando Bacal | Zendy; Pablo Maria Alberto Pomerantzeff | Zendy; Edimar Alcides Bocchi | Zendy; Jorge Kalil | Zendy; Ronaldo Honorato Barros Santos | Zendy; Edécio CunhaNeto | Zendy; Christophe Chevillard | Zendy

Open Access

Whole-Genome Cardiac DNA Methylation Fingerprint and Gene Expression Analysis Provide New Insights in the Pathogenesis of Chronic Chagas Disease Cardiomyopathy

Author(s) -

Laurie Laugier,

Amanda Farage Frade,

Frederico Moraes Ferreira,

Monique Baron,

Priscila Camillo Teixeira,

Sandrine Cabantous,

Ludmila Rodrigues Pinto Ferreira,

Louis Laurence,

Vagner Oliveira Carvalho Rigaud,

Fábio Antônio Gaiotto,

Fernando Bacal,

Pablo Maria Alberto Pomerantzeff,

Edimar Alcides Bocchi,

Jorge Kalil,

Ronaldo Honorato Barros Santos,

Edécio CunhaNeto,

Christophe Chevillard

Publication year - 2017

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cix506

Subject(s) - dna methylation , epigenetics , chagas disease , gene , methylation , pathogenesis , cardiomyopathy , medicine , gene expression , biology , genetics , immunology , heart failure

Chagas disease, caused by the protozoan Trypanosoma cruzi, is endemic in Latin America and affects 10 million people worldwide. Approximately 12000 deaths attributable to Chagas disease occur annually due to chronic Chagas disease cardiomyopathy (CCC), an inflammatory cardiomyopathy presenting with heart failure and arrythmia; 30% of infected subjects develop CCC years after infection. Genetic mechanisms play a role in differential progression to CCC, but little is known about the role of epigenetic modifications in pathological gene expression patterns in CCC patients' myocardium. DNA methylation is the most common modification in the mammalian genome.

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