A Population-Based Assessment of the Impact of 7- and 13-Valent Pneumococcal Conjugate Vaccines on Macrolide-Resistant Invasive Pneumococcal Disease: Emergence and Decline of Streptococcus pneumoniae Serotype 19A (CC320) With Dual Macrolide Resistance Mechanisms | Zendy

Max R. Schroeder | Zendy; Scott Chancey | Zendy; Stephanie Thomas | Zendy; Wan-Hsuan Kuo | Zendy; Sarah W. Satola | Zendy; Monica M. Farley | Zendy; David S. Stephens | Zendy

Open Access

A Population-Based Assessment of the Impact of 7- and 13-Valent Pneumococcal Conjugate Vaccines on Macrolide-Resistant Invasive Pneumococcal Disease: Emergence and Decline of Streptococcus pneumoniae Serotype 19A (CC320) With Dual Macrolide Resistance Mechanisms

Author(s) -

Max R. Schroeder,

Scott Chancey,

Stephanie Thomas,

Wan-Hsuan Kuo,

Sarah W. Satola,

Monica M. Farley,

David S. Stephens

Publication year - 2017

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cix446

Subject(s) - medicine , streptococcus pneumoniae , pneumococcal conjugate vaccine , pneumococcal disease , serotype , population , pneumococcal infections , disease , virology , microbiology and biotechnology , antibiotics , environmental health , biology

Macrolide efflux encoded by mef(E)/mel and ribosomal methylation encoded by erm(B) confer most macrolide resistance in Streptococcus pneumoniae. Introduction of the heptavalent pneumococcal conjugate vaccine (PCV7) in 2000 reduced macrolide-resistant invasive pneumococcal disease (MR-IPD) due to PCV7 serotypes (6B, 9V, 14, 19F, and 23F).

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research