Advanced Human Immunodeficiency Virus Disease in Botswana Following Successful Antiretroviral Therapy Rollout: Incidence of and Temporal Trends in Cryptococcal Meningitis | Zendy

Mark W. Tenforde | Zendy; Margaret Mokomane | Zendy; Tshepo Leeme | Zendy; Raju K K Patel | Zendy; Nametso Lekwape | Zendy; Chandapiwa Ramodimoosi | Zendy; Bonno Dube | Zendy; Elizabeth A. Williams | Zendy; Kelebeletse O. Mokobela | Zendy; Ephraim Tawanana | Zendy; Tlhagiso Pilatwe | Zendy; William James Hurt | Zendy; Hannah K Mitchell | Zendy; Doreen L Banda | Zendy; Hunter H. Stone | Zendy; Mooketsi Molefi | Zendy; Kabelo Mokgacha | Zendy; Heston Phillips | Zendy; Paul C. Mullan | Zendy; Andrew P. Steenhoff | Zendy; Yohana Mashalla | Zendy; Madisa Mine | Zendy; Joseph N Jarvis | Zendy

Open Access

Advanced Human Immunodeficiency Virus Disease in Botswana Following Successful Antiretroviral Therapy Rollout: Incidence of and Temporal Trends in Cryptococcal Meningitis

Author(s) -

Mark W. Tenforde,

Margaret Mokomane,

Tshepo Leeme,

Raju K K Patel,

Nametso Lekwape,

Chandapiwa Ramodimoosi,

Bonno Dube,

Elizabeth A. Williams,

Kelebeletse O. Mokobela,

Ephraim Tawanana,

Tlhagiso Pilatwe,

William James Hurt,

Hannah K Mitchell,

Doreen L Banda,

Hunter H. Stone,

Mooketsi Molefi,

Kabelo Mokgacha,

Heston Phillips,

Paul C. Mullan,

Andrew P. Steenhoff,

Yohana Mashalla,

Madisa Mine,

Joseph N Jarvis

Publication year - 2017

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cix430

Subject(s) - medicine , incidence (geometry) , population , referral , meningitis , pediatrics , antiretroviral therapy , confidence interval , cryptococcosis , disease burden , demography , human immunodeficiency virus (hiv) , immunology , environmental health , viral load , family medicine , physics , sociology , optics

Botswana has a well-developed antiretroviral therapy (ART) program that serves as a regional model. With wide ART availability, the burden of advanced human immunodeficiency virus (HIV) and associated opportunistic infections would be expected to decline. We performed a nationwide surveillance study to determine the national incidence of cryptococcal meningitis (CM), and describe characteristics of cases during 2000-2014 and temporal trends at 2 national referral hospitals.

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