Whole-Genome Sequencing Accurately Identifies Resistance to Extended-Spectrum β-Lactams for Major Gram-Negative Bacterial Pathogens | Zendy

Samuel A. Shelburne | Zendy; Jiwoong Kim | Zendy; José M. Munita | Zendy; Pranoti Sahasrabhojane | Zendy; Ryan K. Shields | Zendy; Ellen G. Press | Zendy; Xiqi Li | Zendy; César A. Arias | Zendy; Brandi L. Cantarel | Zendy; Ying Jiang | Zendy; Min S. Kim | Zendy; Samuel L Aitken | Zendy; David E. Greenberg | Zendy

Open Access

Whole-Genome Sequencing Accurately Identifies Resistance to Extended-Spectrum β-Lactams for Major Gram-Negative Bacterial Pathogens

Author(s) -

Samuel A. Shelburne,

Jiwoong Kim,

José M. Munita,

Pranoti Sahasrabhojane,

Ryan K. Shields,

Ellen G. Press,

Xiqi Li,

César A. Arias,

Brandi L. Cantarel,

Ying Jiang,

Min S. Kim,

Samuel L Aitken,

David E. Greenberg

Publication year - 2017

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cix417

Subject(s) - whole genome sequencing , medicine , broth microdilution , genotype , antibiotic resistance , polymerase chain reaction , drug resistance , gold standard (test) , dna sequencing , microbiology and biotechnology , antibiotics , gene , genome , biology , minimum inhibitory concentration , genetics

There is marked interest in using DNA-based methods to detect antimicrobial resistance (AMR), with targeted polymerase chain reaction (PCR) approaches increasingly being incorporated into clinical care. Whole-genome sequencing (WGS) could offer significant advantages over targeted PCR for AMR detection, particularly for species where mutations are major drivers of AMR.

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