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Congenital Trypanosoma cruzi transmission is now estimated to account for 22% of new infections, representing a significant public health problem across Latin America and internationally. Treatment during infancy is highly efficacious and well tolerated, but current assays for early detection fail to detect &gt;50% of infected neonates, and 9-month follow-up is low.

Toward Improving Early Diagnosis of Congenital Chagas Disease in an Endemic Setting