Toward Improving Early Diagnosis of Congenital Chagas Disease in an Endemic Setting
Author(s) -
Louisa A. Messenger,
Robert H. Gilman,
Manuela Verástegui,
Gerson GaldosCardenas,
Gerardo Sánchez,
Edward Valencia,
Leny Sanchez,
Edith Málaga,
Victoria R. Rendell,
Malasa Jois,
Vishal Shah,
Nicole Santos,
Maria del Carmen Abastoflor,
Carlos LaFuente,
Rony Colanzi,
Ricardo Bozo,
Caryn Bern
Publication year - 2017
Publication title -
clinical infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/cid/cix277
Subject(s) - chagas disease , medicine , trypanosoma cruzi , serology , respiratory distress , pediatrics , antibody , public health , immunology , parasite hosting , pathology , surgery , world wide web , computer science
Congenital Trypanosoma cruzi transmission is now estimated to account for 22% of new infections, representing a significant public health problem across Latin America and internationally. Treatment during infancy is highly efficacious and well tolerated, but current assays for early detection fail to detect >50% of infected neonates, and 9-month follow-up is low.
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