Differential Effects of Prior Influenza Exposures on H3N2 Cross-reactivity of Human Postvaccination Sera | Zendy

Hang Xie | Zendy; Lei Li | Zendy; Zhiping Ye | Zendy; Xing Li | Zendy; Ewan P. Plant | Zendy; Olga Zoueva | Zendy; Yangqing Zhao | Zendy; XiangHong Jing | Zendy; Zhengshi Lin | Zendy; Toshiaki Kawano | Zendy; MengJung Chiang | Zendy; Courtney L. Finch | Zendy; Martina Košíková | Zendy; Anding Zhang | Zendy; Yanhong Zhu | Zendy; XiuFeng Wan | Zendy

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Differential Effects of Prior Influenza Exposures on H3N2 Cross-reactivity of Human Postvaccination Sera

Author(s) -

Hang Xie,

Lei Li,

Zhiping Ye,

Xing Li,

Ewan P. Plant,

Olga Zoueva,

Yangqing Zhao,

XiangHong Jing,

Zhengshi Lin,

Toshiaki Kawano,

MengJung Chiang,

Courtney L. Finch,

Martina Košíková,

Anding Zhang,

Yanhong Zhu,

XiuFeng Wan

Publication year - 2017

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cix269

Subject(s) - hemagglutination assay , vaccination , influenza vaccine , immunology , virology , antigen , medicine , hemagglutination , titer , antibody , original antigenic sin , antigenic drift , cross reactivity , biology , hemagglutinin (influenza) , cross reactions

Effectiveness of seasonal influenza vaccines mainly depends upon how well vaccine strains represent circulating viruses; mismatched strains can lead to reduced protection. Humans have complex influenza exposure histories that increase with age, which may lead to different postvaccination responses to emerging influenza variants. Recent observational studies also suggest that prior vaccination may influence the performance of current seasonal vaccines.

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