Mortality in Severe Human Immunodeficiency Virus-Tuberculosis Associates With Innate Immune Activation and Dysfunction of Monocytes | Zendy

Saskia Janssen | Zendy; Charlotte Schutz | Zendy; Amy Ward | Zendy; Elisa Nemes | Zendy; Katalin A. Wilkinson | Zendy; James Scriven | Zendy; Mischa A. Huson | Zendy; Nanne Aben | Zendy; Gary Maartens | Zendy; Rosie Burton | Zendy; Robert J. Wilkinson | Zendy; Martin P. Grobusch | Zendy; Tom van der Poll | Zendy; Graeme Meintjes | Zendy

Open Access

Mortality in Severe Human Immunodeficiency Virus-Tuberculosis Associates With Innate Immune Activation and Dysfunction of Monocytes

Author(s) -

Saskia Janssen,

Charlotte Schutz,

Amy Ward,

Elisa Nemes,

Katalin A. Wilkinson,

James Scriven,

Mischa A. Huson,

Nanne Aben,

Gary Maartens,

Rosie Burton,

Robert J. Wilkinson,

Martin P. Grobusch,

Tom van der Poll,

Graeme Meintjes

Publication year - 2017

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cix254

Subject(s) - medicine , immunology , tuberculosis , sepsis , mycobacterium tuberculosis , cd14 , population , innate immune system , immune system , pathology , environmental health

Case fatality rates among hospitalized patients diagnosed with human immunodeficiency virus (HIV)-associated tuberculosis remain high, and tuberculosis mycobacteremia is common. Our aim was to define the nature of innate immune responses associated with 12-week mortality in this population.

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