Matrix Degradation in Human Immunodeficiency Virus Type 1–Associated Tuberculosis and Tuberculosis Immune Reconstitution Inflammatory Syndrome: A Prospective Observational Study | Zendy

Naomi F. Walker | Zendy; Katalin A. Wilkinson | Zendy; Graeme Meintjes | Zendy; Liku B. Tezera | Zendy; René Goliath | Zendy; Janique M. Peyper | Zendy; Rebecca Tadokera | Zendy; Charles Opondo | Zendy; Anna K. Coussens | Zendy; Robert J. Wilkinson | Zendy; Jon S. Friedland | Zendy; Paul Elkington | Zendy

Open Access

Matrix Degradation in Human Immunodeficiency Virus Type 1–Associated Tuberculosis and Tuberculosis Immune Reconstitution Inflammatory Syndrome: A Prospective Observational Study

Author(s) -

Naomi F. Walker,

Katalin A. Wilkinson,

Graeme Meintjes,

Liku B. Tezera,

René Goliath,

Janique M. Peyper,

Rebecca Tadokera,

Charles Opondo,

Anna K. Coussens,

Robert J. Wilkinson,

Jon S. Friedland,

Paul Elkington

Publication year - 2017

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cix231

Subject(s) - medicine , tuberculosis , immunology , mycobacterium tuberculosis , coinfection , immune reconstitution inflammatory syndrome , immune system , virology , viral load , virus , pathology , antiretroviral therapy

Extensive immunopathology occurs in human immunodeficiency virus (HIV)/tuberculosis (TB) coinfection, but the underlying molecular mechanisms are not well-defined. Excessive matrix metalloproteinase (MMP) activity is emerging as a key process but has not been systematically studied in HIV-associated TB.

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