Analysis of False-Negative Human Immunodeficiency Virus Rapid Tests Performed on Oral Fluid in 3 International Clinical Research Studies | Zendy

Marcel E. Curlin | Zendy; Roman Gvetadze | Zendy; Wanna Leelawiwat | Zendy; Michael Martin | Zendy; Charles E. Rose | Zendy; Richard W Niska | Zendy; Tebogo Segolodi | Zendy; Kachit Choopanya | Zendy; Jaray Tongtoyai | Zendy; Timothy H. Holtz | Zendy; Taraz Samandari | Zendy; Janet M. McNicholl | Zendy

Open Access

Analysis of False-Negative Human Immunodeficiency Virus Rapid Tests Performed on Oral Fluid in 3 International Clinical Research Studies

Author(s) -

Marcel E. Curlin,

Roman Gvetadze,

Wanna Leelawiwat,

Michael Martin,

Charles E. Rose,

Richard W Niska,

Tebogo Segolodi,

Kachit Choopanya,

Jaray Tongtoyai,

Timothy H. Holtz,

Taraz Samandari,

Janet M. McNicholl

Publication year - 2017

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cix228

Subject(s) - medicine , nucleic acid test , immunoassay , viral load , cohort study , point of care testing , human immunodeficiency virus (hiv) , immunology , antibody , covid-19 , disease , infectious disease (medical specialty)

The OraQuick Advance Rapid HIV-1/2 Test is a point-of-care test capable of detecting human immunodeficiency virus (HIV)-specific antibodies in blood and oral fluid. To understand test performance and factors contributing to false-negative results in longitudinal studies, we examined results of participants enrolled in the Botswana TDF/FTC Oral HIV Prophylaxis Trial, the Bangkok Tenofovir Study, and the Bangkok MSM Cohort Study, 3 separate clinical studies of high-risk, HIV-negative persons conducted in Botswana and Thailand.

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