Short-Course Adjunctive Gentamicin as Empirical Therapy in Patients With Severe Sepsis and Septic Shock: A Prospective Observational Cohort Study | Zendy

David S. Y. Ong | Zendy; Jos F. Frencken | Zendy; Peter M. C. Klein Klouwenberg | Zendy; Nicole P. Juffermans | Zendy; Tom van der Poll | Zendy; Marc J. M. Bonten | Zendy; Olaf L. Cremer | Zendy

Open Access

Short-Course Adjunctive Gentamicin as Empirical Therapy in Patients With Severe Sepsis and Septic Shock: A Prospective Observational Cohort Study

Author(s) -

David S. Y. Ong,

Jos F. Frencken,

Peter M. C. Klein Klouwenberg,

Nicole P. Juffermans,

Tom van der Poll,

Marc J. M. Bonten,

Olaf L. Cremer

Publication year - 2017

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cix186

Subject(s) - medicine , septic shock , interquartile range , gentamicin , sepsis , aminoglycoside , odds ratio , surgery , intensive care medicine , antibiotics , microbiology and biotechnology , biology

Metaanalyses failed to demonstrate clinical benefits of beta lactam plus aminoglycoside combination therapy compared to beta lactam monotherapy in patients with sepsis. However, few data exist on the effects of short-course adjunctive aminoglycoside therapy in sepsis patients with organ failure or shock.

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