Concentration-Dependent Antagonism and Culture Conversion in Pulmonary Tuberculosis | Zendy

Neesha Rockwood | Zendy; Jotam G. Pasipanodya | Zendy; Paolo Denti | Zendy; Frederick A. Sirgel | Zendy; Maia Lesosky | Zendy; Tawanda Gumbo | Zendy; Graeme Meintjes | Zendy; Helen McIlleron | Zendy; Robert J. Wilkinson | Zendy

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Concentration-Dependent Antagonism and Culture Conversion in Pulmonary Tuberculosis

Author(s) -

Neesha Rockwood,

Jotam G. Pasipanodya,

Paolo Denti,

Frederick A. Sirgel,

Maia Lesosky,

Tawanda Gumbo,

Graeme Meintjes,

Helen McIlleron,

Robert J. Wilkinson

Publication year - 2017

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cix158

Subject(s) - cmax , isoniazid , pyrazinamide , rifampicin , culture conversion , tuberculosis , medicine , pharmacology , pharmacodynamics , pharmacokinetics , minimum inhibitory concentration , antibiotics , biology , microbiology and biotechnology , sputum , pathology

There is scant evidence to support target drug exposures for optimal tuberculosis outcomes. We therefore assessed whether pharmacokinetic/pharmacodynamic (PK/PD) parameters could predict 2-month culture conversion.

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