Elevated Pre–Antiretroviral Therapy CD39+CD8+ T Cell Frequency Is Associated With Early Mortality in Advanced Human Immunodeficiency Virus/Tuberculosis Co-infection | Zendy

Shruthi Ravimohan | Zendy; Neo Tamuhla | Zendy; Kebatshabile Nfanyana | Zendy; Houping Ni | Zendy; Andrew P. Steenhoff | Zendy; Robert Gross | Zendy; Drew Weissman | Zendy; Gregory P. Bisson | Zendy

Open Access

Elevated Pre–Antiretroviral Therapy CD39+CD8+ T Cell Frequency Is Associated With Early Mortality in Advanced Human Immunodeficiency Virus/Tuberculosis Co-infection

Author(s) -

Shruthi Ravimohan,

Neo Tamuhla,

Kebatshabile Nfanyana,

Houping Ni,

Andrew P. Steenhoff,

Robert Gross,

Drew Weissman,

Gregory P. Bisson

Publication year - 2017

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cix155

Subject(s) - medicine , tuberculosis , immunology , antiretroviral therapy , cd8 , immune reconstitution inflammatory syndrome , immune system , human immunodeficiency virus (hiv) , immunopathology , aids related opportunistic infections , virology , sida , viral disease , viral load , pathology

Correlates of death soon after antiretroviral therapy (ART) initiation remain unclear. We investigated the association between expression of CD39, a novel immune exhaustion marker, and early mortality in patients with human immunodeficiency virus/tuberculosis co-infection. Elevated pre-ART CD39+CD8+ T cell frequency was independently associated with mortality within 6 months of ART initiation.

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