Seeding and Establishment of Legionella pneumophila in Hospitals: Implications for Genomic Investigations of Nosocomial Legionnaires’ Disease | Zendy

Sophia David | Zendy; Baharak Afshar | Zendy; M. Mentasti | Zendy; Christophe Ginévra | Zendy; Isabelle Podglajen | Zendy; Simon R. Harris | Zendy; Victoria J. Chalker | Zendy; Sophie Jarraud | Zendy; Timothy G. Harrison | Zendy; Julian Parkhill | Zendy

Open Access

Seeding and Establishment of Legionella pneumophila in Hospitals: Implications for Genomic Investigations of Nosocomial Legionnaires’ Disease

Author(s) -

Sophia David,

Baharak Afshar,

M. Mentasti,

Christophe Ginévra,

Isabelle Podglajen,

Simon R. Harris,

Victoria J. Chalker,

Sophie Jarraud,

Timothy G. Harrison,

Julian Parkhill

Publication year - 2017

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cix153

Subject(s) - legionnaires' disease , legionella pneumophila , legionella , hospital acquired pneumonia , medicine , ventilator associated pneumonia , typing , population , whole genome sequencing , multilocus sequence typing , outbreak , community acquired pneumonia , pneumonia , intensive care medicine , microbiology and biotechnology , biology , virology , genome , genotype , bacteria , genetics , environmental health , gene

Legionnaires' disease is an important cause of hospital-acquired pneumonia and is caused by infection with the bacterium Legionella. Because current typing methods often fail to resolve the infection source in possible nosocomial cases, we aimed to determine whether whole-genome sequencing (WGS) could be used to support or refute suspected links between cases and hospitals. We focused on cases involving a major nosocomial-associated strain, L. pneumophila sequence type (ST) 1.

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