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Association of C-Reactive Protein With Bacterial and Respiratory Syncytial Virus–Associated Pneumonia Among Children Aged <5 Years in the PERCH Study
Author(s) -
Melissa M. Higdon,
Tham Le,
Katherine L. O’Brien,
David R. Murdoch,
Christine Prosperi,
Henry C. Baggett,
W. Abdullah Brooks,
Daniel R. Feikin,
Laura L. Hammitt,
Stephen R. C. Howie,
Karen L. Kotloff,
Orin S. Levine,
J. Anthony G. Scott,
Donald M. Thea,
Juliet O. Awori,
Vicky L. Baillie,
Stephanie Cascio,
Somchai Chuana,
Andrea N. DeLuca,
Amanda J. Driscoll,
Bernard E. Ebruke,
Hubert P. Endtz,
Anek Kaewpan,
Geoff Kahn,
Angela Karani,
Ruth A. Karron,
David P. Moore,
Daniel E. Park,
Mohammed Ziaur Rahman,
Rasheed Salaudeen,
Phil Seidenberg,
Somwe Wa Somwe,
Mamadou Sylla,
Milagritos D. Tapia,
Scott L. Zeger,
Maria Deloria Knoll,
Shabir A. Madhi
Publication year - 2017
Publication title -
clinical infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/cid/cix150
Subject(s) - pneumonia , medicine , bacterial pneumonia , c reactive protein , sputum , microbiological culture , etiology , respiratory disease , immunology , gastroenterology , lung , pathology , biology , bacteria , inflammation , genetics , tuberculosis
Lack of a gold standard for identifying bacterial and viral etiologies of pneumonia has limited evaluation of C-reactive protein (CRP) for identifying bacterial pneumonia. We evaluated the sensitivity and specificity of CRP for identifying bacterial vs respiratory syncytial virus (RSV) pneumonia in the Pneumonia Etiology Research for Child Health (PERCH) multicenter case-control study.

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