Reduced Immunoglobulin (Ig) G Response to Staphylococcus aureus in STAT3 Hyper-IgE Syndrome | Zendy

Sebastian Stentzel | Zendy; Beate Hagl | Zendy; Felicitas Abel | Zendy; Barbara C. Kahl | Zendy; Anita Rack-Hoch | Zendy; Barbara M. Bröker | Zendy; Ellen D. Renner | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Reduced Immunoglobulin (Ig) G Response to Staphylococcus aureus in STAT3 Hyper-IgE Syndrome

Author(s) -

Sebastian Stentzel,

Beate Hagl,

Felicitas Abel,

Barbara C. Kahl,

Anita Rack-Hoch,

Barbara M. Bröker,

Ellen D. Renner

Publication year - 2017

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cix140

Subject(s) - staphylococcus aureus , medicine , immunoglobulin e , immunology , antibody , immunoglobulin g , staphylococcal infections , cystic fibrosis , immunoglobulin a , microbiology and biotechnology , biology , bacteria , genetics

STAT3 hyper-IgE syndrome (STAT3-HIES) patients presented with significantly lower Staphylococcus aureus-specific serum IgG compared to cystic fibrosis patients despite recurrent S. aureus infections. Immunoglobulin replacement therapy increased S. aureus-specific IgG in STAT3-HIES patients and attenuated the clinical course of disease suggesting a role of humoral immunity in S. aureus clearance.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research