Posttreatment Reactions After Single-Dose Diethylcarbamazine or Ivermectin in Subjects With Loa loa Infection
Author(s) -
Jesica A. Herrick,
Fanny Legrand,
Racéline Kamkumo Gounoue,
Godwin Nchinda,
Céline Montavon,
Jean Bopda,
Steve Mbickmen Tchana,
Bienvenu Etogo Ondigui,
Konrad Nguluwe,
Michael P. Fay,
Michelle Makiya,
Simon Metenou,
Thomas B. Nutman,
Joseph Kamgno,
Amy D. Klion
Publication year - 2017
Publication title -
clinical infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/cid/cix016
Subject(s) - ivermectin , loa loa , diethylcarbamazine , medicine , onchocerciasis , eosinophil , lymphatic filariasis , adverse effect , lymphocyte , immunology , pathophysiology , gastroenterology , physiology , filariasis , veterinary medicine , helminths , asthma
Severe adverse reactions have been observed in individuals with Loa loa infection treated with either diethylcarbamazine (DEC), the drug of choice for loiasis, or ivermectin (IVM), which is used in mass drug administration programs for control of onchocerciasis and lymphatic filariasis in Africa. In this study, posttreatment clinical and immunologic reactions were compared following single-dose therapy with DEC or IVM to assess whether these reactions have the same underlying pathophysiology.
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