Single Dose Versus 3 Doses of Intramuscular Benzathine Penicillin for Early Syphilis in HIV: A Randomized Clinical Trial | Zendy

Roberto Andrade | Zendy; Maria C. RodriguezBarradas | Zendy; Kosuke Yasukawa | Zendy; Erick Villarreal | Zendy; Michael W. Ross | Zendy; José A. Serpa | Zendy

Open Access

Single Dose Versus 3 Doses of Intramuscular Benzathine Penicillin for Early Syphilis in HIV: A Randomized Clinical Trial

Author(s) -

Roberto Andrade,

Maria C. RodriguezBarradas,

Kosuke Yasukawa,

Erick Villarreal,

Michael W. Ross,

José A. Serpa

Publication year - 2017

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciw862

Subject(s) - medicine , rapid plasma reagin , regimen , syphilis , titer , randomized controlled trial , randomization , surgery , immunology , human immunodeficiency virus (hiv) , treponema , antibody

Patients coinfected with syphilis and human immunodeficiency virus (HIV) may have a slower decrease in rapid plasma reagin (RPR) titers. Currently a single dose of 2.4 million units of intramuscular benzathine penicillin G (BPG) is recommended for the treatment of early syphilis. Some observational studies have suggested that this regimen may lead to high failure rates in coinfected patients.

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