Comparative Effectiveness and Safety of Standard-, Medium-, and High-Dose Daptomycin Strategies for the Treatment of Vancomycin-Resistant Enterococcal Bacteremia Among Veterans Affairs Patients | Zendy

Nicholas Britt | Zendy; Emily Potter | Zendy; Nimish Patel | Zendy; Molly E. Steed | Zendy

Open Access

Comparative Effectiveness and Safety of Standard-, Medium-, and High-Dose Daptomycin Strategies for the Treatment of Vancomycin-Resistant Enterococcal Bacteremia Among Veterans Affairs Patients

Author(s) -

Nicholas Britt,

Emily Potter,

Nimish Patel,

Molly E. Steed

Publication year - 2016

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciw815

Subject(s) - daptomycin , medicine , hazard ratio , bacteremia , vancomycin , retrospective cohort study , dosing , confidence interval , proportional hazards model , gastroenterology , surgery , antibiotics , staphylococcus aureus , microbiology and biotechnology , biology , bacteria , genetics

Vancomycin-resistant Enterococcus bloodstream infections (VRE-BSIs) are associated with significant mortality. Daptomycin exhibits concentration-dependent activity vs VRE in vitro, yet the clinical impact of higher-dose strategies remains unclear.

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