Early Clinical Response as a Predictor of Late Treatment Success in Patients With Acute Bacterial Skin and Skin Structure Infections: Retrospective Analysis of 2 Randomized Controlled Trials | Zendy

Dilip Nathwani | Zendy; Ralph Corey | Zendy; Anita Das | Zendy; Taylor Sandison | Zendy; Carisa De Anda | Zendy; Philippe Prokocimer | Zendy

Open Access

Early Clinical Response as a Predictor of Late Treatment Success in Patients With Acute Bacterial Skin and Skin Structure Infections: Retrospective Analysis of 2 Randomized Controlled Trials

Author(s) -

Dilip Nathwani,

Ralph Corey,

Anita Das,

Taylor Sandison,

Carisa De Anda,

Philippe Prokocimer

Publication year - 2016

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciw750

Subject(s) - medicine , predictive value , clinical trial , randomized controlled trial , intensive care medicine

In the treatment of acute bacterial skin and skin structure infections, pooled data from 2 clinical trials (N = 1333 patients) showed that programmatic and investigator-assessed early treatment success both had a high positive predictive value (94.3%-100.0%) for late clinical cure, including among hospitalized patients. The negative predictive value of programmatic early success was <20%. These exploratory findings require prospective real-world evaluation.

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