Therapeutic Immune Recovery and Reduction of CXCR4-Tropic HIV-1 | Zendy

Joëlle Bader | Zendy; Martin Däumer | Zendy; F. Schöni-Affolter | Zendy; Jürg Böni | Zendy; Meri Gorgievski-Hrisoho | Zendy; G Martinetti | Zendy; Alexander Thielen | Zendy; Thomas Klimkait | Zendy

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Therapeutic Immune Recovery and Reduction of CXCR4-Tropic HIV-1

Author(s) -

Joëlle Bader,

Martin Däumer,

F. Schöni-Affolter,

Jürg Böni,

Meri Gorgievski-Hrisoho,

G Martinetti,

Alexander Thielen,

Thomas Klimkait

Publication year - 2016

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciw737

Subject(s) - provirus , cart , tropism , virology , medicine , virus , tissue tropism , viral load , cxcr4 , immunology , population , viral disease , immune system , biology , genetics , genome , chemokine , gene , mechanical engineering , environmental health , engineering

In the absence of therapy, CXCR4 (X4)-tropic human immunodeficiency virus type 1 (HIV-1) increases over time, associated with accelerated disease progression. In contrast, the majority of patients receiving long-term combination antiretroviral therapy (cART) present with CCR5 (R5)-tropic HIV-1 variants. It is unclear whether cART itself mediates the reduction of X4-tropic HIV-1. The current study aimed at assessing the tropism of viral integrates in patients' blood during fully suppressive cART.

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