Thymic Function Impacts the Peripheral CD4/CD8 Ratio of HIV-Infected Subjects
Author(s) -
Isaac RosadoSánchez,
Inés Herrero-Fernández,
Miguel Genebat,
Ezequiel RuizMateos,
M. Leal,
Yolanda M. Pacheco
Publication year - 2016
Publication title -
clinical infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/cid/ciw711
Subject(s) - medicine , cd4 cd8 ratio , peripheral , cd8 , immunology , human immunodeficiency virus (hiv) , function (biology) , virology , lymphocyte subsets , immune system , biology , genetics
The persistence of an inverted CD4/CD8 ratio has been extensively associated with the increased morbimortality of chronic human immunodeficiency virus (HIV)-infected subjects. Thymic function is crucial for the maintenance of T cell homeostasis. We explored the impact of thymic function on the CD4/CD8 ratio of HIV-infected subjects.
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