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Congenital Cytomegalovirus Infection: Prognostic Value of Maternal DNAemia at Amniocentesis
Author(s) -
Giuliana Simonazzi,
Francesca Cervi,
Alice Zavatta,
Laura Pellizzoni,
Brunella Guerra,
Marianna Mastroroberto,
Antonio Maria MorselliLabate,
Liliana Gabrielli,
Nicola Rizzo,
Tiziana Lazzarotto
Publication year - 2016
Publication title -
clinical infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/cid/ciw700
Subject(s) - medicine , human cytomegalovirus , amniocentesis , seroconversion , pregnancy , viremia , cytomegalovirus , odds ratio , betaherpesvirinae , immunology , fetus , herpesviridae , prenatal diagnosis , viral disease , antibody , virus , biology , genetics
Human Cytomegalovirus (HCMV) is the most common cause of childhood hearing loss and can lead to neurodevelopmental delay. To date, few studies have examined the correlation between maternal viremia and congenital HCMV infection. The aim of our study was to ascertain if HCMV DNA in the peripheral blood of pregnant women with primary HCMV infection at the time of amniocentesis may have a prognostic value in terms of congenital infection and neonatal symptomatic disease.

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