Cervicovaginal Inflammation Facilitates Acquisition of Less Infectious HIV Variants | Zendy

Philippe Selhorst | Zendy; Lindi Masson | Zendy; Sherazaan D. Ismail | Zendy; Natasha Samsunder | Zendy; Nigel Garrett | Zendy; Leila E. Mansoor | Zendy; Quarraisha Abdool Karim | Zendy; Salim S. Abdool Karim | Zendy; JoAnn S. Passmore | Zendy; Carolyn Williamson | Zendy

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Cervicovaginal Inflammation Facilitates Acquisition of Less Infectious HIV Variants

Author(s) -

Philippe Selhorst,

Lindi Masson,

Sherazaan D. Ismail,

Natasha Samsunder,

Nigel Garrett,

Leila E. Mansoor,

Quarraisha Abdool Karim,

Salim S. Abdool Karim,

JoAnn S. Passmore,

Carolyn Williamson

Publication year - 2016

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciw663

Subject(s) - inflammation , medicine , immunology , human immunodeficiency virus (hiv) , transmission (telecommunications) , sex organ , virus , virology , phenotype , viral disease , biology , gene , genetics , electrical engineering , engineering

We evaluated whether genital inflammation affects the selection of the transmitted virus. Among South African women, we found that preinfection genital inflammation facilitates transmission of less infectious human immunodeficiency virus, but highly infectious viruses are able to establish infection regardless of inflammation status. This suggests that viral phenotype can influence transmission risk.

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