Asymptomatic CMV Replication During Early Human Immunodeficiency Virus (HIV) Infection Is Associated With Lower CD4/CD8 Ratio During HIV Treatment | Zendy

Davey M. Smith | Zendy; Masato Nakazawa | Zendy; Michael L. Freeman | Zendy; Christy M. Anderson | Zendy; Michelli F. Oliveira | Zendy; Susan J. Little | Zendy; Sara Gianella | Zendy

Open Access

Asymptomatic CMV Replication During Early Human Immunodeficiency Virus (HIV) Infection Is Associated With Lower CD4/CD8 Ratio During HIV Treatment

Author(s) -

Davey M. Smith,

Masato Nakazawa,

Michael L. Freeman,

Christy M. Anderson,

Michelli F. Oliveira,

Susan J. Little,

Sara Gianella

Publication year - 2016

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciw612

Subject(s) - subclinical infection , medicine , immunology , asymptomatic , cd8 , viral load , cd4 cd8 ratio , virus , viral replication , virology , human cytomegalovirus , immune system , lymphocyte subsets

A low CD4/CD8 ratio in human immunodeficiency virus (HIV)-infected individuals is associated with inflammation and higher risk of non-AIDS morbidity and mortality. In this study, we investigated the effect of subclinical cytomegalovirus (CMV) and Epstein-Barr virus (EBV) replication on CD4 + and CD8 + T-cell dynamics when antiretroviral therapy (ART) is started during early infection.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research