The Spectrum of Serious Infections Among Patients Receiving Immune Checkpoint Blockade for the Treatment of Melanoma
Author(s) -
María del Carmen López Castillo,
Fabián Andrés Rosas Romero,
Esther Argüello,
Chrisann Kyi,
Michael A. Postow,
Gil RedelmanSidi
Publication year - 2016
Publication title -
clinical infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/cid/ciw539
Subject(s) - medicine , blockade , immune checkpoint , pembrolizumab , melanoma , nivolumab , retrospective cohort study , infliximab , immune system , oncology , immunology , immunotherapy , tumor necrosis factor alpha , cancer research , receptor
The risk of infection among patients receiving immune checkpoint blockade is unknown. We retrospectively reviewed medical records of 740 patients with melanoma who received immune checkpoint blockers. Serious infection occurred in 54 patients (7.3%). The main risk factors were receipt of corticosteroids and/or infliximab.
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